H2N2V1, Main, Exploration, bibRecord, 001B31

Virulence-associated sequence duplication at the hemagglutinin cleavage site of avian influenza viruses

Identifieur interne : 001B31 ( Main/Exploration ); précédent : 001B30; suivant : 001B32

Virulence-associated sequence duplication at the hemagglutinin cleavage site of avian influenza viruses

Auteurs : Michael L. Perdue [États-Unis] ; Maricarmen Garc A [États-Unis] ; Dennis Senne [États-Unis] ; M. Fraire [Mexique]

Source :

Virus Research [ 0168-1702 ] ; 1997.

RBID : ISTEX:A3ED3A7202E9C901451B20E51E9221E2D2415617

English descriptors

Teeft :
- Amino, Amino acid sequence, Amino acid sequences, Amino acids, Animal health association, Arginine, Avian, Avian virus, Avian viruses, Boca raton, Central mexico, Cleavage, Cleavage site, Cleavage site sequence, Coding sequence, Codon, Commercial poultry, Conferences services, Consensus sequence, Direct duplication, General model, Glycoprotein cleavage site, Hairpin, Hairpin structure, Hemagglutinin, Hemagglutinin cleavage site, Hemagglutinin gene, Insertion, Nucleotide, Nucleotide sequence, Nucleotide sequences, Nucleotide substitutions, Other duplications, Outbreak, Pathogenic, Pathogenic phenotype, Pathogenicity, Perdue, Perkin elmer, Phylogenetic, Phylogenetic analyses, Phylogenetic relationships, Polymerase, Positive sense, Purine, Purine content, Same hairpin structure, Secondary structure, Sequence duplication, Sequencing, Single purines, Spontaneous duplication, States department, Substitution, Virus, Virus research, Western poultry disease conf, Wisconsin genetics computer group, Zuker.

Abstract

Abstract: Recent highly pathogenic (HP) field isolates of avian influenza (AI) virus from Mexico all possess an insertion of at least two basic amino acids (arg-lys) at the cleavage site of the hemagglutinin (HA) glycoprotein. One HP isolate has additional information which yields a 4 amino acid insert (arg-lys-arg-lys). We present here the nucleotide sequence of the HA gene of this unique isolate and compare it to recent H5N2 and other avian influenza isolates. The complete HA nucleotide sequence of the isolate and phylogenetic relationship suggest that it was derived in direct succession from a non-pathogenic strain isolated about 1 month earlier. The unique insertion sequence is a direct duplication of part of the purine-rich region preceding the arginine codon at the HA cleavage site. This evidence along with other data in this report provide compelling support for a proposed model explaining the mechanism of spontaneous, virulence-related insertions in type A influenza viruses.

Url:

https://api.istex.fr/ark:/67375/6H6-LC1PCNDN-M/fulltext.pdf

DOI: 10.1016/S0168-1702(97)01468-8

Affiliations:

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Le document en format XML

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<author><name sortKey="Garc A, Maricarmen" sort="Garc A, Maricarmen" uniqKey="Garc A M" first="Maricarmen" last="Garc A">Maricarmen Garc A</name>
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<author><name sortKey="Fraire, M" sort="Fraire, M" uniqKey="Fraire M" first="M." last="Fraire">M. Fraire</name>
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<term>Animal health association</term>
<term>Arginine</term>
<term>Avian</term>
<term>Avian virus</term>
<term>Avian viruses</term>
<term>Boca raton</term>
<term>Central mexico</term>
<term>Cleavage</term>
<term>Cleavage site</term>
<term>Cleavage site sequence</term>
<term>Coding sequence</term>
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<term>Consensus sequence</term>
<term>Direct duplication</term>
<term>General model</term>
<term>Glycoprotein cleavage site</term>
<term>Hairpin</term>
<term>Hairpin structure</term>
<term>Hemagglutinin</term>
<term>Hemagglutinin cleavage site</term>
<term>Hemagglutinin gene</term>
<term>Insertion</term>
<term>Nucleotide</term>
<term>Nucleotide sequence</term>
<term>Nucleotide sequences</term>
<term>Nucleotide substitutions</term>
<term>Other duplications</term>
<term>Outbreak</term>
<term>Pathogenic</term>
<term>Pathogenic phenotype</term>
<term>Pathogenicity</term>
<term>Perdue</term>
<term>Perkin elmer</term>
<term>Phylogenetic</term>
<term>Phylogenetic analyses</term>
<term>Phylogenetic relationships</term>
<term>Polymerase</term>
<term>Positive sense</term>
<term>Purine</term>
<term>Purine content</term>
<term>Same hairpin structure</term>
<term>Secondary structure</term>
<term>Sequence duplication</term>
<term>Sequencing</term>
<term>Single purines</term>
<term>Spontaneous duplication</term>
<term>States department</term>
<term>Substitution</term>
<term>Virus</term>
<term>Virus research</term>
<term>Western poultry disease conf</term>
<term>Wisconsin genetics computer group</term>
<term>Zuker</term>
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<front><div type="abstract" xml:lang="en">Abstract: Recent highly pathogenic (HP) field isolates of avian influenza (AI) virus from Mexico all possess an insertion of at least two basic amino acids (arg-lys) at the cleavage site of the hemagglutinin (HA) glycoprotein. One HP isolate has additional information which yields a 4 amino acid insert (arg-lys-arg-lys). We present here the nucleotide sequence of the HA gene of this unique isolate and compare it to recent H5N2 and other avian influenza isolates. The complete HA nucleotide sequence of the isolate and phylogenetic relationship suggest that it was derived in direct succession from a non-pathogenic strain isolated about 1 month earlier. The unique insertion sequence is a direct duplication of part of the purine-rich region preceding the arginine codon at the HA cleavage site. This evidence along with other data in this report provide compelling support for a proposed model explaining the mechanism of spontaneous, virulence-related insertions in type A influenza viruses.</div>
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Virulence-associated sequence duplication at the hemagglutinin cleavage site of avian influenza viruses

Virulence-associated sequence duplication at the hemagglutinin cleavage site of avian influenza viruses

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri